Virtual Agenda

Thursday, December 7, 2023

6:45 am Pre-Registration

7:00 am – 8:00 am Exhibit Hall Opens | Coffee

7:00 pm – 7:45 pm Breakfast Session Non-CME-Education Product Theater Hall

BMF-219: An Oral Menin Inhibitor in Clinical Development as a Short-term Therapy

to Address the Root Cause of Diabetes, Beta-cell Dysfunction

Supported by Biomea Fusion

Speakers:

Priyanka Somanath, PhD Thomas Butler, MS, MBA Rohit N. Kulkarni, MD, PhD Juan Frias, MD

8:00 am – 8:15 am Welcome & Introduction | Pre-CME Questions Yehuda Handelsman, MD

Session 1 Endothelium and Cardiometabolic Disorders

8:15 am – 9:30 am Chairs: Vivian Fonseca * Derek LeRoith, MD

8:15 am The Effects of RYGB on Cholesterol and Bile Acid Metabolism in Humans Bart Staels, PhD

8:35 am Endothelial-Mesenchymal Transition in Cardiovascular Disease (EndMT) Jorge Plutzky, MD

8:55 am The Role of SGLTx in ACS, A. Fib & Metabolism- A Translational Approach Robert J. Chilton, DO

9:15 am – 9:30 am Panel Discussion and Q&A

Session 2 ASCVD Epidemiology, Pathophysiology & Management

9:30 am – 10:45 am Chairs: Ron Krauss, MD * Robert Chilton, MD

9:30 am Importance of Cardiovascular Risk Assessment and Multiple Risk Factor Control in Diabetes Nathan D. Wong, PhD

9:50 am Common Molecular Mechanisms Drive Cardiometabolic and Vascular Diseases Outcomes- Clinical Implications W. Timothy Garvey, MD

10:10 am The Relationships Between HDL Dysfunction, Genetic Very Small LDL, CAC and Insulin Resistance Arthur S. Agatston, MD

10:30 am – 10:45 am Panel Discussion and Q&A

10:45 am – 11:15 am REFRESHMENT BREAK at the Exhibit Hall

Session 3 Lipidology Toward 2024- Panel Session

11:15 am – 12:10 pm Chairs: Erin Michos, MD * Chris Guerin, MD

11:15 am The Role of the Mitochondrial/ER Axis in Cholesterol Metabolism and Statin Myopathy Ronald M. Krauss, MD

Lpa, CETP / BA-CLEAR / Very High HDL Seth S. Martin, MD, MHS

Discussions and Q&A Arthur S. Agatston, MD

12:10 pm

Session 4 Concurrent Sessions: Meet the Experts

12:15 pm – 1:00 pm 45 mins

Ralph A. DeFronzo, MD Insulin Resistance – Intensive Management of DM Mandarin AB

Vivian A. Fonseca, MD DCRM Risk Prediction Sierra CD (Lecture Hall)

Jennifer Green, MD CKD Emerging Strategies Club

Yehuda Handelsman, MD Technology in DM and CRM Salon 6AB

1:00 pm – 2:00 pm LUNCH BREAK

1:10 pm – 1:55 pm Lunch Session Non-CME Product Theater Hall

Jardiance® (empagliflozin) tablets: A Peer Review of the Latest
Clinical Data and Dosing Recommendations

Supported by BI/Lilly Christian Mende, MD

Session 5 Metabolic Science

2:00 pm – 2:50 pm Chairs: Richard Bergman, PhD * Phillip Scherer, PhD

2:00 pm Genome- Proteome- Phenome & Mendelian Randomization Studies, Elucidating Novel Pathways

and Treatments-Clinical Implication in Cardiometabolic Disorders Christos S. Mantzoros, MD, PhD

2:20 pm The Role of mRNA Modifications in the Regulation of Metabolism Rohit N. Kulkarni, MD, PhD

2:40 pm – 2:50 pm Panel Discussion and Q&A

Session 6 The Future of HTN

2:50 pm – 3:40 pm Chairs: Pam Taub, MD * Chris Mende, MD

2:50 pm Refractory HTN and New Drugs & Procedures in the Future Norman Lepor, MD

3:10 pm Need for New agents to Overcome Healthcare Disparity in Hypertension Keith Ferdinand, MD

3:30 pm – 3:40 pm Panel Discussion and Q&A

Session 7 DCRM 2.0 – Update and Global Transformation

3:40pm – 4:10 pm Chairs: Richard Pratley, MD * Matt Weir MD

3:40 am DCRM 2.0 - Diabetes CardioRenal & Metabolic Diseases- Update & Global Yehuda Handelsman, MD

3:55 pm – 4:10 pm Panel Discussion and Q&A

4:10 pm – 4:40 pm REFRESHMENT BREAK at the Exhibit Hall

Session 8 Insulin Resistance, Diabetes, and Beyond

5:00 pm – 6:30 pm Chairs: Jennifer Green, MD *Jorge Plutzky, MD

4:40 pm Brain HDL and Alzheimer’s Disease: Toward Therapeutic Applications Hussein Yassine, MD

5:00 pm Pulmonary Disease in Diabetes- Another Final Frontier? Peter J. Grant, MD

5:20 pm Contemporary Nomenclature of Fatty Liver Disease Impact on Diagnosis and Management Rohit Loomba, MD, MHSc

5:40 pm Vascular Aging in CKD Matthew R. Weir, MD

6:00pm Management of Diabetes in Patients with Cancer Addressing Impact of Cancer Therapy
Overcoming Treatment Challenges: Management of Patients with Diabetes and Cancer

Emily J Gallagher, MD, PhD

6:20 pm – 6:35 pm Panel Discussion and Q&A

6:35pm – 7:30 pm WELCOME & POSTER RECEPTION AT EXHIBIT HALL

7:30 pm – 9:15 pm Dinner CME Symposium Supported by AstraZeneca

Winning the Trifecta of Diabetes, the Heart and Kidney Diseases

Chairs: Yehuda Handelsman, MD • Muthiah Vaduganathan, MD, MPH

7:30 pm Introduction & Pre-CME Questions Muthiah Vaduganathan, MD, MPH

7:40 pm Early Intervention in Diabetes Addressing Pathophysiology in Preventing Comorbidities Vivian A. Fonseca , MD

8:00 pm SGLT2i Effects Across the Spectrum of CKD and Multiple Populations Peter Rossing, MD

8:20 pm Impact of SGLT2i on HF Outcomes in Various Populations & the Range of LVEF Muthiah Vaduganathan, MD, MPH

8:40 pm Panel Discussion and Q&A: Changing the Trajectory of Heart Failure and CKD, Implementing Guidelines Directed Medical Therapy

Panel: Vivian A. Fonseca, MD • Christian W. Mende, MD • Erin D. Michos, MD, MHS • Peter Rossing, MD •

Muthiah Vaduganathan, MD, MPH

Moderator: Yehuda Handelsman, MD

9:10 pm Concluding Remarks & Post-CME Questions

9:15 pm Adjourn

FRIDAY, DECEMBER 8, 2023

7:00 am Registration

7:00 am – 8:00 am EXHIBIT HALL OPENS

7:00 am – 7:45 am Breakfast Session Non-CME Product Theater Hall

“The Dual Dilemma: Navigating Cardiorenal Risk in CKD Associated with T2D” Supported by Bayer Dharmesh S. Patel, MD, MBBS

Dharmesh S. Patel, MD, MBBS

8:00 am – 8:15 am Summary of Day 1 and Pre-CME Questions Zachary Bloomgarden, MD

Session 9 Women’s Health

8:15 am – 9:05 am Chairs: Ania Jastrenboff, MD * Pam Taub, MD

8:15 am Infertility, Assisted Reproductive Technology, and Cardiovascular Risk Erin D. Michos, MD, MHS

8:35 am Sex Differences in Cardiovascular Risk Associated with Pre, Newly Diagnosed, and Undiagnosed- Diabetes

Vivian A. Fonseca, MD

8:55 am – 9:05 am Panel Discussion and Q&A

Session 10 The Multiple Faces of Insulin Resistance

9:05 am – 10:20 am Chairs: Ralph A. DeFronzo, MD • Peter Grant, MD

9:05 am Insulin Resistance in T2DM: Whole Body, Organ, Cellular, and Molecular Pathogenesis Ralph A. DeFronzo, MD

9:25 am Insulin Resistance and Myocardial Energy Metabolism: Implications for Therapy E. Dale Abel, MD, PhD

9:45 am Which Comes First: Insulin Resistance or Obesity? Samuel Klein, MD

10:05 am – 10:20 am Panel Discussion and Q&A

10:20 am – 10:50 am REFRESHMENT BREAK at the Exhibit Hall

Session 11 Progress in Pediatric Obesity and T2D: New and Advanced Treatments

10:50 pm – 12:05 pm Chairs: Sonia Caprio, MD • Alan R. Sinaiko, MD

10:50 am GLP-1 RA for the Treatment of Youth Onset Obesity and T2D: From Fantasy to Reality Silva Arslanian, MD

11:10 am Achieving Metabolic Homeostasis in Youth with Obesity, Prediabetes/T2D and NAFLD,

Using Semaglutide 2, 4 mg. Sonia Caprio, MD

11:30 am Novel Treatments on the Horizon for Youth with Obesity, Fatty Liver & T2D Rohit Kohli MBBS, MS 11:50 am – 12:05 pm Panel Discussion and Q&A

12:05 pm – 1:05 pm LUNCH BREAK

12:15 pm – 1:00 pm Lunch Session Non-CME Product Theater Hall

Mounjaro® (tirzepatide) Product Theater Steven Edelman, MD

Supported by Lilly

Session 12 Joint Session with Metabolism

1:00 pm – 2:20 pm Chairs: Christos S. Mantzoros, MD, PhD * Tracey Mclaughlin, MD, MS

1:00 pm Introduction and Updates on The Metabolism Journal Christos S. Mantzoros, MD, PhD

1:05 pm Vascular Mineralocorticoid Receptors, Vascular Insulin Sensitivity in Cardiometabolic Disorders:

From Physiology to Clinical Relevance Michael A. Hill, PhD

1:25 pm Metabolic Surgery Important Role in the Comprehensive Management of Metabolic Diseases Geltrude Mingrone, M.D., Ph.D

1:45 pm Cardiorenal Protection with SGLT2 Inhibitors: From Physiology to Clinical Outcomes

to the Future in Heart Failure and Diabetic Kidney Disease David Cherney, MDCM, PhD

2:05 pm – 2:20 pm Faculty Panel Discussion and Q&A

Session 13 Non-CME: A Glimpse into the Future - What’s in the Pipeline?

2:20 pm – 3:20 pm Chairs: Ralph A. DeFronzo, MD • Christos S. Mantzoros, MD, PhD

2:20 pm Regeneron Boaz Hirshberg, MD

2:35 pm Esperion Stephen L. Pinkosky, PhD

2:50 pm Corcept Joseph Belanoff, MD

3:05 pm – 3:20 pm Panel Discussion and Q&A

3:20 pm – 4:35 pm Refreshment Break at the Exhibit Hall

3:40 pm – 4:25 pm Break-Reception Session Non-CME Education Product Theater Hall

The Evolving Cardiovascular-Renal-Metabolic Paradigm: How can healthcare systems better match science? Supported by Boehringer-Ingelheim

Speaker: Pamela Kushner, MD David Cherney, MD Yehuda Handelsman, MD

Session 14 Contemporary Management of Diabetes

4:35 pm – 6:15 pm Chairs: George Grunberger MD * Paul Jellinger, MD

4:35 pm Molecular Mechanisms by which Glucagon Regulates Hepatic Mitochondrial Oxidation and Gluconeogenesis – Implications for Dual and Triple GLP-1 Analogs Gerald I. Shulman, MD, PhD

4:55 pm Incretins in Diabetes- The New, The Newest and the Future Richard E. Pratley, MD

5:15 pm CGM in People Without Diabetes Tracey L. McLaughlin, MD, MS

5:35pm Overcoming Clinical Inertia: The COORDINATE- Diabetes Example Jennifer B. Green, MD

5:55 pm – 6:15pm Faculty Panel Discussion and Q&A

6:15 pm – 7:30pm Dinner CME Symposium Supported by Lexicon Pharmaceuticals

Breaking New Ground in Heart Failure Treatment

Chairs: Matthew Budoff, MD • Yehuda Handelsman, MD

6:15 pm Introduction & Pre CME Questions Yehuda Handelsman, MD

6:25 pm Prevalence, Pathophysiology and Morbidities of Heart Failure Mathew Budoff, MD

6:40 pm Contemporary Approach to Management of Heart Failure Stephen Greene, MD

6:55 pm Sotagliflozin: The Next Generation of Heart Failure Management Darren McGuire, MD, MHSc

7:10 pm Panel Discussion, Q&A, and Post-CME: Advancing the Care of Heart Failure- Relationship to CKD

Panel: Mathew Budoff, MD • Stephen Greene, MD • Darren McGuire, MD, MHSc • Matthew Weir, MD

Moderator: Yehuda Handelsman

7:25 pm Post-CME Questions & Concluding Remarks

7:30 pm Adjourn

7:30pm - 9:00 pm Abstract Oral Presentation Cheese and wine will be served.

Chair: Zachary T., Bloomgarden, MD

Abstract Committee: Ralph A. DeFronzo, MD • Vivian A. Fonseca, MD • George Grunberger, MD •

Derek LeRoith, MD • Philip Levy, MD • Christian W. Mende, MD • Richard E. Pratley, MD

• Matthew R. Weir, MD

Abstracts are published in Metabolism Editor-in-Chief: Christos S. Mantzoros, MD, PhD

SATURDAY, DECEMBER 9, 2023

7:00 am Registration

7:00 am – 7:45 am Breakfast Session Non-CME Education Product Theater Hall

"Evolving Perspectives in Hyperglycemia Secondary to Hypercortisolism: A Retrospective Look"

Supported by Corcept

Ralph A. DeFronzo, MD Yehuda Handelsman, MD Daniel Einhorn, MD

8:00 am – 8:05 am Oral Abstract Winner Award Presentation Zachary Bloomgarden, MD

8:05 am – 8:20 am Summary of Day 2 and Pre-CME Questions Zachary Bloomgarden, MD

Session 15 Cardiomyopathy & Heart Failure- Panel Session

8:20 am – 10:00 am Chairs: Niko Marx, MD * Mikhail Kosiborod, MD

8:20 am Contemporary Approach to Cardiac Amyloidosis Michelle M. Kittleson, MD, PhD

Cardiomyopathy and Pregnancy Uri Elkayam, MD

The role of Diuretics in Heart Failure Stephen J. Greene, MD

Management of Heart Failure: Bridging the Gap Between Evidence and Practice Gregg C. Fonarow, MD

Discussions and Q&A

10:00 am

10:00 am – 10:10 am REFRESHMENT BREAK

Session 16 CVOT & Guidelines

10:10 am – 11:00 am Chairs: Peter J. Grant, MD * Matt Weir, MD

10:10 am CVOTs Update Mikhail N. Kosiborod MD

10:30 am 2023 ESC Diabetes and Cardiovascular Disease Guidelines Nikolaus Marx, MD

10:50 am – 11:00 am Panel Discussion and Q&A

Session 17 Gerald Reaven Distinguished Leader in Insulin Resistance 2023 Award

11:00 am Award Presentation by Peter J. Grant, MD Samual Klein, MD

11:05 am Insulin Resistance and its outcomes in T2DM: A Historical and Epidemiological Perspective Paul Zimmet AO, MD, PhD

11:35 am – 11:45 am Q&A

11:45 am – 12:45 pm LUNCH & CHECK-OUT BREAK

11:55 am – 12:40 pm Lunch Session Non-CME Product Theater Hall

“Innovation and Improved Outcomes with Abbott Diabetes Care”

Supported by Abbott George Grunberger, MD

Session 18 Fat Mass and Adipocyte

12:45 pm – 1:35 pm Chairs: Richard Pratley, MD * Bart Staels, PhD

12:45 pm The Role of Relative Fat Mass- RFM vs. BMI Predicting T2D, Heart Failure and CVD Richard N. Bergman, PhD

1:05 pm GIP-R Action in the Adipocyte Philipp E. Scherer, PhD

1:25 pm – 1:35 pm Panel Discussion and Q&A

Session 19 Contemporary Approach to Obesity- Panel Session

1:35 pm – 2:55 pm Chairs: Samuel Klein, MD • W. Timothy Garvey, MD

1:35 pm Nutrient-Stimulated Hormone-Based Therapies for Obesity Treatment:

Clinical Application and Pipeline Ania Jastreboff, MD, PhD Diets, Calorie Restrictions vs Intermittent Fasting Addressing the Energy Balance Model Eric Ravussin, PhD

Weight and Weight Changes Impact on CV Risk Neha J. Pagidipati, MD, MPH

Discussions and Q&A: Does the Availability of Effective Pharmacotherapy
to Treat Obesity Negates the Need for the Other Treatment Options?

2:55 pm

2:55 pm – 3:10 pm Refreshment Break

Session 20 Not All Diabetes – is Type 2 DM

3:10 pm – 4:00 pm Chairs: Paul Zimmet, MD * Zachary Bloomgarden, MD

3:10 pm Diabetes Secondary to Pancreatitis Mark O. Goodarzi, MD, PhD

3:30 pm 2023 Prevention and Management of T1D- the New Reality George Grunberger, MD

3:50 pm – 4:00 pm Panel Discussion and Q&A

Session 21 ASCVD Imaging- Panel Session Cheese and Wine

4:00 pm – 5:00 pm Chairs: Matthew J. Budoff, MD • Norman Lepor, MD

4:00 pm Imaging in Predicting Subacute Atherosclerosis

CTA in Predicting Survival- the CONFIRM Registry

Association of Coronary Artery Calcium & Spine Bone Density

Comparing Plaques in Patients with & without Statins +/- DM

Discussions and Q&A Matthew J. Budoff, MD Michael Joseph Blaha, MD, MPH

5:00 pm

Session 22 Concurrent Sessions: Clinical Workshop Hors d'oeuvres

5:00 pm – 6:00 pm

Lipids Paul S. Jellinger, MD & Paul D. Rosenblit, MD, PhD Sierra C/D (Lecture Hall)

Diabetes George Grunberger, MD Sierra B HTN/CKD Christian Mende, MD Hiro

6:00 pm Adjourn

#WCIRDC24

CME Conference on December 12-14, 2024
Hilton Universal Hotel Los Angeles
555 Universal Hollywood Dr, Universal City, CA 91608

Agenda

2023 WCIRDC AGENDA

Headquarters & Administration