|Early Intervention In The Continuum Of Hyperglycemia - The Role of Initial Combination Therapy
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Ralph A. DeFronzo, MD
Professor of Medicine
Chief, Diabetes Division
University of Texas Health Science
Center Deputy Director,
Texas Diabetes Institute
San Antonio, Texas
Zachary T. Bloomgarden, MD / Chair
Clinical Professor of Medicine
Mount Sinai School of Medicine
Assistant Attending in Medicine
Mount Sinai Hospital
Consultant in Endocrinology
New York, New York
Samuel Dagogo- Jack, MD
A.C. Mullins Chair in Translational Research
Professor of Medicine & Director,
Division of Endocrinology, Diabetes & Metabolism
President, Medicine & Science,
American Medical Association
Director, Clinical Research Center
University of Tennessee Health Science Center
Yehuda Handelsman MD, FACP, FACE, FNLA / Chair
Chair & Program Director
World Congress Insulin Resistance,
DM & CVD
Medical Director & Principal Investigator
Metabolic Institute of America
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In the past, a major challenge in safely treating type 2 diabetes was in controlling glucose without inducing hypoglycemia and weight gain. Additionally many patients were largely unmonitored due to the antiquated approach of introducing new therapies only after failure. In recent years new agents were developed. The incretin based therapy, namely GLP1-RA and DPP4i, help improve insulin secretion and reduce endogenous glucose production; and SGLT2 inhibitors, which reduce glucose re-absorption, have been approved for the management of type 2 diabetes. The development of appropriate and safe therapeutic pathways led to new approaches in reaching and maintaining glycemic control. Early intervention in the continuum of hyperglycemia, often in combination, has the potential to slow the progression of diabetes and allows reaching desired goals safely. This program will address the change in paradigm in managing diabetes and lead the clinician in developing treatment modalities which do not cause failure but rather reach success by implementing early intervention in combination achieving goals safely, while also impacting CV risk factors like blood pressure, weight and reduced complications.
1) Describe diabetes as a continuum of hyperglycemia with its progressive and accumulated complications.
2) Explain how early and intensive intervention may halt, if not reverse, progression to complications.
3) Discuss the contemporary approach to managing diabetes addressing all risk factors.
4) Analyze early intervention strategies with combination medications to achieve fast control to reduce complications.
5) Describe the benefit of novel therapy specifically incretins and SLGT2 inhibitor and the potential effect beyond glycemia on weight, blood pressure, and the kidney.
This activity has been planned and implemented in accordance with the Essenntial Areas and policies of the Accreditation Council for Continuing Medical Eduation through the joint sponsorship of PESI, Inc and Metabolic Endocrine Education Fundation (MEEF). PESI, Inc is accredited by the ACCME to provide continuing medical education for physicians. The PESI, Inc designated this enduring educational activity maximum of 2.0 ama pra Category 1 Credits(s). Physicians should only claim credit commensurate With the extent of their participation in the activity.
Duration: Duration 2.00 hours you will earn 2 FREE AMA PRA Category 1 Credit(s)™
Based on live Satellite Symposium of 13th WCIRCD.
Date of release: December 31st, 2015
Date of expiration: December 31st, 2016
This educational initiative is designed for Endocrinologists, cardiologists, family physicians, internists, diabetologists, nurse practitioners, and other health care professionals interested in diabetes and obesity.
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Program Provided By
Metabolic Endocrine Education Foundation (MEEF)
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Acknowledgement of Support
This is a CME Program Supported by an Educational Grant from Astrazeneca
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Faculty Disclosures and Conflicts of Interest
It is the policy of PESI, Inc., Aspen CME Services and the Metabolic Endocrine Education Foundation, accreditors of this live educational activity that anyone that can affect the content of an educational activity must provide disclosure of financial relationships that they or their partner may have with commercial supporters. Speakers are also required to disclose if their presentation will contain information on off-labeled, investigational, or unapproved use of a product.
Aspen CME Services is approved by the California Board of Registered Nursing, provider number CEP14739, has designated this activity for 2.00 contact hours. For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credit TM issued by organizations accredited by the ACCME. State pharmacy boards accept AMA PRA Category 1 Credit TM issued by organizations accredited by the ACCME.
The planning faculty, speakers, and moderators for this activity have provided the following information:
||Novo Nordisk & AstraZeneca=Speaker's Bureau; AstraZeneca, Novo Nordisk, Janssen, Lexicon & BI=Advisory Board; Janssen, BI, Takeda & AstraZeneca=Research Grant Attestation
||AstraZeneca, Janssen, Novo Nordisk & Merck=Speaker; AstraZeneca, Janssen, NovoNordisk, Merck, Amgen & Novartis=Consultant; Baxter Int'l, CVS Carmark, Roche Holdings, St Jude Medical & Novartis=Stockholder
||Amgen, BI, Gilead, Intarcia, GSK, Lexicon, Merck, Novo Nordisk, Sanofi & Takeda=Research Grant; Amarin, Amgen, (Amlylin) BMS, BI, diaDeux, DSI, Eisai, Gilead, GSK, Halozyme, Hanssen, LipoScience, Merck, Novo Nordisk, Sanofi, Santarus & Vivus=Consultant; Amarin, AstraZeneca-BMS(Amylin), BI-Lilly, DSI, GSK, Hanssen, Novo Nordisk, Santarus & Vivus=Speaker's Bureau
||AstraZeneca, Novo Nordisk & BI=Investigator on Clinical trials; Merck, Novo Nordisk & Janssen=Consultant
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education, through the joint providership of PESI, Inc, and the Metabolic Endocrine Education Foundation (MEEF). PESI, Inc is accredited by the ACCME to provide continuing medication education for physicians.
AMA PRA Designation Statement
PESI, Inc designates this enduring activity for a maximum of 2.00 AMA PRA Category 1 credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity.
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No part of this publication may be reproduced or transmitted in any other form or by any other means, electronic or mechanical, without first obtaining written permission © 2015-2016 MEEF
For questions regarding this CME activity, please contact us
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